Pub. Date : 2017 Aug 21
PMID : 28564555
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Holocarboxylase Synthetase: A Moonlighting Transcriptional Coregulator of Gene Expression and a Cytosolic Regulator of Biotin Utilization. | Biotin | holocarboxylase synthetase | Homo sapiens |
| 2 | Biotin is attached to apocarboxylases by a biotin ligase: holocarboxylase synthetase (HCS) in mammalian cells and BirA in microbes. | Biotin | holocarboxylase synthetase | Homo sapiens |
| 3 | Biotin is attached to apocarboxylases by a biotin ligase: holocarboxylase synthetase (HCS) in mammalian cells and BirA in microbes. | Biotin | holocarboxylase synthetase | Homo sapiens |
| 4 | Biotin is attached to apocarboxylases by a biotin ligase: holocarboxylase synthetase (HCS) in mammalian cells and BirA in microbes. | Biotin | holocarboxylase synthetase | Homo sapiens |
| 5 | Biotin is attached to apocarboxylases by a biotin ligase: holocarboxylase synthetase (HCS) in mammalian cells and BirA in microbes. | Biotin | holocarboxylase synthetase | Homo sapiens |
| 6 | However, beyond its role in metabolism, HCS participates in the regulation of biotin utilization and acts as a nuclear transcriptional coregulator of gene expression. | Biotin | holocarboxylase synthetase | Homo sapiens |
| 7 | We suggest that HCS be classified as a moonlighting protein, with two biotin-dependent cytosolic metabolic roles and a distinct biotin-independent nuclear coregulatory function. | Biotin | holocarboxylase synthetase | Homo sapiens |
| 8 | We suggest that HCS be classified as a moonlighting protein, with two biotin-dependent cytosolic metabolic roles and a distinct biotin-independent nuclear coregulatory function. | Biotin | holocarboxylase synthetase | Homo sapiens |