Title : Quantifying Na(I)-insulin and K(I)-insulin non-covalent complexes by ESI-MS method and calculation of their equilibrium constants.

Pub. Date : 2017 Oct

PMID : 28554793






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1 Quantifying Na(I)-insulin and K(I)-insulin non-covalent complexes by ESI-MS method and calculation of their equilibrium constants. Sodium Iodide insulin Homo sapiens
2 In this study, the dissociation and formation equilibrium constants of Na(I)-insulin and K(I)-insulin complexes have been calculated after the quantifying them on ESI mass spectrometer. Sodium Iodide insulin Homo sapiens
3 In this study, the dissociation and formation equilibrium constants of Na(I)-insulin and K(I)-insulin complexes have been calculated after the quantifying them on ESI mass spectrometer. Sodium Iodide insulin Homo sapiens
4 The effect of pH on the Na(I)-insulin and K(I)-insulin complex formation were examined. Sodium Iodide insulin Homo sapiens
5 The first formation equilibrium constants were calculated as Kf1: 5.48x103 1/M for Na(I)-insulin complex and Kf1: 4.87x103 1/M for K(I)-insulin in water. Sodium Iodide insulin Homo sapiens
6 The first formation equilibrium constants were calculated as Kf1: 5.48x103 1/M for Na(I)-insulin complex and Kf1: 4.87x103 1/M for K(I)-insulin in water. Sodium Iodide insulin Homo sapiens
7 The results showed that Na(I) and K(I) ions are involved in the formation of the non-covalent complexes with insulin molecule, since high extracellular and intracellular concentrations of them in the body. Sodium Iodide insulin Homo sapiens