Pub. Date : 2017 Aug
PMID : 28554582
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | A Rac inhibitor, and N17Rac1 dominant negative mutant, significantly induced PCSK9 levels, and a suppression of Rac1 expression by siRNA, counteract the effect of simvastatin on the induction of PCSK9 mRNA. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |
2 | Finally, simvastatin, and Rac inhibitor inhibited the nuclear translocation of STAT3 and its knock-down by siRNA increased significantly the susceptibility of Caco-2 to simvastatin on PCSK9 expression. | Simvastatin | AKT serine/threonine kinase 1 | Homo sapiens |