Title : Geranylgeraniol prevents the simvastatin-induced PCSK9 expression: Role of the small G protein Rac1.

Pub. Date : 2017 Aug

PMID : 28554582






2 Functional Relationships(s)
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Protein Name
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1 A Rac inhibitor, and N17Rac1 dominant negative mutant, significantly induced PCSK9 levels, and a suppression of Rac1 expression by siRNA, counteract the effect of simvastatin on the induction of PCSK9 mRNA. Simvastatin AKT serine/threonine kinase 1 Homo sapiens
2 Finally, simvastatin, and Rac inhibitor inhibited the nuclear translocation of STAT3 and its knock-down by siRNA increased significantly the susceptibility of Caco-2 to simvastatin on PCSK9 expression. Simvastatin AKT serine/threonine kinase 1 Homo sapiens