Title : Wnt/β-catenin signaling plays an essential role in α7 nicotinic receptor-mediated neuroprotection of dopaminergic neurons in a mouse Parkinson's disease model.

Pub. Date : 2017 Sep 15

PMID : 28551099






2 Functional Relationships(s)
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1 In the in vivo study, alpha7-nAChR knockout (alpha7-KO) reversed the beneficial effects of nicotine on motor deficits, dopaminergic neuron loss, astrocyte and microglia activation, and reduced striatal dopamine release induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus
2 Injury to SH-SY5Y cells by 1-methyl-4-phenylpyridinium treatment was also ameliorated by nicotine, and this effect was abolished by methyllycaconitine (MLA), a selective alpha7-nAChR antagonist, or by siRNA-mediated alpha7-nAChR knockdown. Nicotine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus