Title : Statins Attenuate Activation of the NLRP3 Inflammasome by Oxidized LDL or TNFα in Vascular Endothelial Cells through a PXR-Dependent Mechanism.

Pub. Date : 2017 Sep

PMID : 28546421






1 Functional Relationships(s)
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1 Simvastatin or mevastatin significantly suppressed the effects of ox-LDL or TNFalpha Promoter reporter assays and small interfering RNA knockdown revealed that statins inhibit ox-LDL-mediated NLRP3 inflammasome activation via the pregnane X receptor (PXR). Simvastatin tumor necrosis factor Homo sapiens