Title : Gonadotropin-releasing hormone-stimulated phosphoinositide hydrolysis in the anterior pituitary. Modulation by protein kinase C but not by cyclic nucleotides.

Pub. Date : 1988 Nov

PMID : 2854223






2 Functional Relationships(s)
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1 Protein kinase C activators attenuated GnRH-induced phosphoinositide hydrolysis, while neither cyclic AMP analogs nor cyclic GMP analogs were effective. Phosphatidylinositols gonadotropin releasing hormone 1 Rattus norvegicus
2 These results indicate that phosphoinositide hydrolysis represents an important postreceptor transducing mechanism for GnRH action at the gonadotroph and that protein kinase C (but not cyclic nucleotides) may exert a negative feedback control on GnRH receptor-coupling mechanisms. Phosphatidylinositols gonadotropin releasing hormone 1 Rattus norvegicus