Title : Inhibition of N-acetylglucosaminyltransferase V enhances the cetuximab-induced radiosensitivity of nasopharyngeal carcinoma cells likely through EGFR N-glycan alterations.

Pub. Date : 2017 Aug 1

PMID : 28535302






2 Functional Relationships(s)
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1 N-acetylglucosaminyltransferase V (GnT-V), an enzyme that catalyses the formation of the N-linked beta-1-6 branching of oligosaccharides, is related to the radiosensitivity of nasopharyngeal carcinoma (NPC). Oligosaccharides UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens
2 The results from two NPC cell lines (CNE1 and CNE2) revealed that the silencing of GnT-V enhanced cetuximab-induced radiosensitivity by decreasing the beta-1-6 branching of oligosaccharides on the EGFR. Oligosaccharides UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 Homo sapiens