Title : Thiol-reactive drug substrates of human P-glycoprotein label the same sites to activate ATPase activity in membranes or dodecyl maltoside detergent micelles.

Pub. Date : 2017 Jul 8

PMID : 28533092






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Similarly, the presence of DM did not alter the locations of other drug-binding sites since the thiol reactive forms of the substrates verapamil or rhodamine labeled the same sites in transmembrane segments 5 (I306C for verapamil) and 6 (F343C for rhodamine) whether P-gp was in native membranes or in detergent micelles. Verapamil ATP binding cassette subfamily B member 1 Homo sapiens