Title : Immediate and delayed potentiating effects of tumor necrosis factor-α on TRPV1 sensitivity of rat vagal pulmonary sensory neurons.

Pub. Date : 2017 Aug 1

PMID : 28522561






1 Functional Relationships(s)
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1 First, a brief pretreatment with a low dose of TNFalpha (1.44 nM, 9 min) enhanced the sensitivity of transient receptor potential vanilloid type 1 (TRPV1) receptors in these neurons in two distinct phases: the inward current evoked by capsaicin was amplified (Delta = 247%) immediately following the TNFalpha pretreatment, which gradually declined toward control and then increased again reaching another peak (Delta = 384%) after 60-90 min. Capsaicin tumor necrosis factor Rattus norvegicus