Pub. Date : 2017 Aug 1
PMID : 28521025
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | In our study, we found a new pathway underlying As2O3-induced cardiotoxicity that As2O3 accelerates lysosomal degradation of hERG on plasma membrane after using brefeldin A (BFA) to block protein trafficking. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
2 | In our study, we found a new pathway underlying As2O3-induced cardiotoxicity that As2O3 accelerates lysosomal degradation of hERG on plasma membrane after using brefeldin A (BFA) to block protein trafficking. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
3 | Then we explored pharmacological rescue strategies on As2O3-induced LQTS, and found that 4 therapeutic agents exert rescue efficacy via 3 different pathways: fexofenadine and astemizole facilitate hERG trafficking via promotion of channel-chaperone formation after As2O3 incubation; ranolazine slows hERG degradation in the presence of As2O3; and resveratrol shows significant attenuation on calcium current increase triggered by As2O3. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |
4 | Then we explored pharmacological rescue strategies on As2O3-induced LQTS, and found that 4 therapeutic agents exert rescue efficacy via 3 different pathways: fexofenadine and astemizole facilitate hERG trafficking via promotion of channel-chaperone formation after As2O3 incubation; ranolazine slows hERG degradation in the presence of As2O3; and resveratrol shows significant attenuation on calcium current increase triggered by As2O3. | Arsenic Trioxide | ETS transcription factor ERG | Homo sapiens |