Pub. Date : 2017 May 30
PMID : 28507119
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | However, physiological concentrations of testosterone and hydrocortisone inhibited CatSper activation by progesterone. | Progesterone | cation channel sperm associated 1 | Homo sapiens |
| 2 | Interestingly, both compounds competed with progesterone and pregnenolone sulfate and significantly reduced CatSper activation by either steroid. | Progesterone | cation channel sperm associated 1 | Homo sapiens |
| 3 | These results indicate that (i) pregnenolone sulfate together with progesterone are the main steroids that activate CatSper and (ii) pristimerin and lupeol can act as contraceptive compounds by averting sperm hyperactivation, thus preventing fertilization. | Progesterone | cation channel sperm associated 1 | Homo sapiens |