Title : Inhibitory effect of glycyrrhetinic acid on testosterone production in rat gonads.

Pub. Date : 1988 Apr

PMID : 2850159






2 Functional Relationships(s)
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1 When 14C-labeled androstenedione was incubated with microsomal fraction of testicular or ovarian tissue, glycyrrhizin and glycyrrhetinic acid inhibited the conversion of androstenedione to testosterone, indicating that these compounds inhibit the activity of 17 beta-hydroxysteroid dehydrogenase (EC. Androstenedione aldo-keto reductase family 1, member C12 Rattus norvegicus
2 When 14C-labeled androstenedione was incubated with microsomal fraction of testicular or ovarian tissue, glycyrrhizin and glycyrrhetinic acid inhibited the conversion of androstenedione to testosterone, indicating that these compounds inhibit the activity of 17 beta-hydroxysteroid dehydrogenase (EC. Androstenedione aldo-keto reductase family 1, member C12 Rattus norvegicus