Title : Resistance to RET-Inhibition in RET-Rearranged NSCLC Is Mediated By Reactivation of RAS/MAPK Signaling.

Pub. Date : 2017 Aug

PMID : 28500237






3 Functional Relationships(s)
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1 Ponatinib is a multi-kinase inhibitor with low-nanomolar potency against the RET kinase domain. ponatinib ret proto-oncogene Homo sapiens
2 Here, we demonstrate that ponatinib exhibits potent antiproliferative activity in RET fusion-positive LC-2/ad lung adenocarcinoma cells and inhibits phosphorylation of the RET fusion protein and signaling through ERK1/2 and AKT. ponatinib ret proto-oncogene Homo sapiens
3 Here, we demonstrate that ponatinib exhibits potent antiproliferative activity in RET fusion-positive LC-2/ad lung adenocarcinoma cells and inhibits phosphorylation of the RET fusion protein and signaling through ERK1/2 and AKT. ponatinib ret proto-oncogene Homo sapiens