Title : Possible Role of Organic Cation Transporters in the Distribution of [11C]Sulpiride, a Dopamine D2 Receptor Antagonist.

Pub. Date : 2017 Sep

PMID : 28499878






5 Functional Relationships(s)
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1 From in vitro experiments, we found that sulpiride is a substrate of hOCT1 (Km 2.6 muM), hOCT2 (Km 68 muM), hMATE1 (Km 40 muM), and hMATE2-K (Km 60 muM). Sulpiride latexin Homo sapiens
2 From in vitro experiments, we found that sulpiride is a substrate of hOCT1 (Km 2.6 muM), hOCT2 (Km 68 muM), hMATE1 (Km 40 muM), and hMATE2-K (Km 60 muM). Sulpiride latexin Homo sapiens
3 From in vitro experiments, we found that sulpiride is a substrate of hOCT1 (Km 2.6 muM), hOCT2 (Km 68 muM), hMATE1 (Km 40 muM), and hMATE2-K (Km 60 muM). Sulpiride latexin Homo sapiens
4 From in vitro experiments, we found that sulpiride is a substrate of hOCT1 (Km 2.6 muM), hOCT2 (Km 68 muM), hMATE1 (Km 40 muM), and hMATE2-K (Km 60 muM). Sulpiride latexin Homo sapiens
5 Moreover, the uptake of sulpiride by human hepatocytes was diminished by tetraethylammonium, and saturable with Km of 18 muM. Sulpiride latexin Homo sapiens