Pub. Date : 2017 Jul
PMID : 28498637
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | It has been suggested that beta2-adrenergic receptor (beta2-AR)-mediated signaling induced by catecholamines regulates the degradation of p53. | Catecholamines | adrenoceptor beta 2 | Homo sapiens |
| 2 | It has been suggested that beta2-adrenergic receptor (beta2-AR)-mediated signaling induced by catecholamines regulates the degradation of p53. | Catecholamines | adrenoceptor beta 2 | Homo sapiens |
| 3 | In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating beta2-AR-mediated signaling pathway, since selective beta2-AR antagonist ICI 118, 551 and non-selective beta-blocker proprenolol effectively repressed isoproterenol (ISO)-induced Sirt1 expression. | Catecholamines | adrenoceptor beta 2 | Homo sapiens |
| 4 | In the present study, we demonstrated that catecholamines upregulated the expression of silent information regulator 1 (Sirt1) through activating beta2-AR-mediated signaling pathway, since selective beta2-AR antagonist ICI 118, 551 and non-selective beta-blocker proprenolol effectively repressed isoproterenol (ISO)-induced Sirt1 expression. | Catecholamines | adrenoceptor beta 2 | Homo sapiens |
| 5 | In addition, we demonstrated that catecholamines induced resistance of cervical cancer cells to chemotherapeutics both in vitro and in vivo and that beta2-AR was overexpressed in cervical cancer tissues. | Catecholamines | adrenoceptor beta 2 | Homo sapiens |
| 6 | Our data suggest that the p53-dependent, chemotherapeutics-induced cytotoxicity in cervical cancer cells may be compromised by catecholamines-induced upregulation of the Sirt1 expression through activating the beta2-AR signaling. | Catecholamines | adrenoceptor beta 2 | Homo sapiens |