Title : Proinflammatory effects of S100A8/A9 via TLR4 and RAGE signaling pathways in BV-2 microglial cells.

Pub. Date : 2017 Jul

PMID : 28498464






1 Functional Relationships(s)
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1 Furthermore, S100A8/A9 markedly enhanced the nuclear translocation of NF-kappaB p65 and the DNA-binding activities of NF-kappaB in BV-2 microglial cells, and suppression of ERK and JNK/MAPK signaling pathways by PD98059 or SP600125 significantly inhibited NF-kappaB activity and the release of TNF-alpha and IL-6 in the S100A8/A9-treated BV-2 microglial cells. pyrazolanthrone nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus