Title : Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-κB.

Pub. Date : 2017 Jul

PMID : 28495310






3 Functional Relationships(s)
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1 Resveratrol inhibits urban particulate matter-induced COX-2/PGE2 release in human fibroblast-like synoviocytes via the inhibition of activation of NADPH oxidase/ROS/NF-kappaB. Resveratrol mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 In the present study, we demonstrated that resveratrol reduced PM-induced COX-2/PGE2 expression in human FLSs, and attenuated PM-enhanced NADPH oxidase activity and ROS generation. Resveratrol mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 Thus, we concluded that resveratrol functions as a suppressor of PM-induced inflammatory signaling pathways by inhibiting COX-2/PGE2 expression. Resveratrol mitochondrially encoded cytochrome c oxidase II Homo sapiens