Pub. Date : 2017 Aug
PMID : 28493050
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fasudil could reduce the elevated tumor necrosis factor (TNF)-alpha (70.2 +- 14.1 vs. 25.3 +- 5.2) and transforming growth factor (TGF-beta) levels and restored the deficit in antioxidant level of the diabetic aorta. | fasudil | tumor necrosis factor | Rattus norvegicus |
| 2 | In conclusion, the present study demonstrates that fasudil effectively ameliorates the endothelial dysfunction in STZ-induced diabetic rats through inhibition of the Rho/ROCK pathway and thereby reducing the TNF-alpha-mediated NADPH oxidase activation. | fasudil | tumor necrosis factor | Rattus norvegicus |