Title : Competitive Inhibition Mechanism of Acetylcholinesterase without Catalytic Active Site Interaction: Study on Functionalized C60 Nanoparticles via in Vitro and in Silico Assays.

Pub. Date : 2017 Jun 7

PMID : 28492309






1 Functional Relationships(s)
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1 Specifically, the fullerene core covered the enzyme gorge as a lid through pi-pi stacking with Tyr72 and Trp286 in the PAS, while the hydrophobic ligands on the fullerene surface inserted into the AChE active site to provide further stability for the complexes. Aminosalicylic Acid acetylcholinesterase (Cartwright blood group) Homo sapiens