Pub. Date : 2017
PMID : 28490015
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Salidroside Attenuates Ventilation Induced Lung Injury via SIRT1-Dependent Inhibition of NLRP3 Inflammasome. | rhodioloside | NLR family, pyrin domain containing 3 | Mus musculus |
| 2 | SDS treatment inhibited the activation of NLRP3 inflammasome and subsequent caspase-1 cleavage as well as interleukin (IL)-1beta secretion both in vivo and in vitro. | rhodioloside | NLR family, pyrin domain containing 3 | Mus musculus |
| 3 | Importantly, knockdown of SIRT1 reversed the inhibitory effect of SDS on NLRP3 inflammasome activation. | rhodioloside | NLR family, pyrin domain containing 3 | Mus musculus |
| 4 | CONCLUSIONS: Taken together, these findings indicate that SDS may confer protection against ventilation induced lung injury via SIRT1-de-pendent inhibition of NLRP3 inflammasome activation. | rhodioloside | NLR family, pyrin domain containing 3 | Mus musculus |