Title : Rapamycin regulates macrophage activation by inhibiting NLRP3 inflammasome-p38 MAPK-NFκB pathways in autophagy- and p62-dependent manners.

Pub. Date : 2017 Jun 20

PMID : 28489580






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1 Therefore, our results suggest that rapamycin negatively regulates macrophage activation by restricting a feedback loop of NLRP3 inflammasome-p38 MAPK-NFkappaB pathways in autophagy- and p62/SQSTM1-dependent manners. Sirolimus NLR family pyrin domain containing 3 Homo sapiens