Pub. Date : 2017 Jul 11
PMID : 28484083
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | As expected, the combination of etoposide and cisplatin synergistically inhibited HM-1 cell proliferation. | Etoposide | cholinergic receptor muscarinic 1 | Homo sapiens |
| 2 | Strikingly, when etoposide and cisplatin were combined with PI3K inhibitor BEZ235, the growth of HM-1 cells was significantly reduced. | Etoposide | cholinergic receptor muscarinic 1 | Homo sapiens |
| 3 | Taken together, the data implied the combination of etoposide and cisplatin with BEZ235 not only inhibited HM-1 cell proliferation but also increased cell apoptosis. | Etoposide | cholinergic receptor muscarinic 1 | Homo sapiens |
| 4 | Next, HM-1 was treated with PI3K inhibitors, BKM120 and/or BEZ235, in combination with two well-known genotoxic drugs, etoposide and/or cisplatin, to evaluate which combination could serve as a more effective treatment approach. | Etoposide | cholinergic receptor muscarinic 1 | Homo sapiens |