Pub. Date : 2017 Aug
PMID : 28479391
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Differential cytotoxic activity of Quercetin on colonic cancer cells depends on ROS generation through COX-2 expression. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 2 | Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 3 | Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 4 | Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 5 | Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 6 | Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 7 | Increased generation of reactive oxygen species (ROS) was observed only in Quercetin treated HT29 cells, which is due to over expression of COX-2, as COX-2 silencing inhibited Quercetin induced apoptosis and ROS generation. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 8 | Insilico analysis provided evidence that Quercetin could partially inhibit COX-2 enzyme by binding to subunit A which has peroxidase activity and serves as source of ROS. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |
| 9 | To conclude, differential sensitivity of two cancer cells, HT29 and HCT15, to Quercetin depends on COX-2 dependent ROS generation that induces apoptosis and inhibits cell survival. | Reactive Oxygen Species | mitochondrially encoded cytochrome c oxidase II | Homo sapiens |