Title : Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity.

Pub. Date : 2017 Jun 5

PMID : 28478157






1 Functional Relationships(s)
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1 In the present study, the activities of 15 recombinant human GSTs and NQO1 in the inactivation of reactive QIs of AQ and its pharmacological active metabolite, N-desethylamodiaquine (DEAQ) were investigated. Amodiaquine NAD(P)H quinone dehydrogenase 1 Homo sapiens