Title : Anti-inflammatory action of 2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone (CMEP-NQ) suppresses both the MyD88-dependent and TRIF-dependent pathways of TLR4 signaling in LPS-stimulated RAW264.7 cells.

Pub. Date : 2017 Jun 9

PMID : 28465253






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1 MATERIALS AND METHODS: Anti-inflammatory activity of CMEP-NQ was investigated in LPS-treated RAW264.7 cells by measuring the levels of NO, PGE2, and cytokines (IL1beta, IL-6, TNF-alpha) in the culture supernatants and the TLR4-mediated intracellular events including association of MyD88 with IRAK1, activation of IRAK1, TAK1, MAPKs, NF-kappaB/AP-1, and IRF3, and generation of ROS. 2-carbomethoxy-2,3-epoxy-3-prenyl-1,4-naphthoquinone interleukin 1 beta Mus musculus