Pub. Date : 2017
PMID : 28463985
20 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Palmitic acid is a toll-like receptor 4 ligand that induces human dendritic cell secretion of IL-1beta. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 2 | Palmitic acid (PA) and other saturated fatty acids are known to stimulate pro-inflammatory responses in human immune cells via Toll-like receptor 4 (TLR4). | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 3 | Palmitic acid (PA) and other saturated fatty acids are known to stimulate pro-inflammatory responses in human immune cells via Toll-like receptor 4 (TLR4). | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 4 | Palmitic acid (PA) and other saturated fatty acids are known to stimulate pro-inflammatory responses in human immune cells via Toll-like receptor 4 (TLR4). | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 5 | Palmitic acid (PA) and other saturated fatty acids are known to stimulate pro-inflammatory responses in human immune cells via Toll-like receptor 4 (TLR4). | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 6 | Here, we demonstrate that PA functions as a ligand for TLR4 on human monocyte derived dendritic cells (MoDCs). | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 7 | Hydrophobicity protein modeling indicated PA can associate with the hydrophobic binding pocket of TLR4 adaptor protein MD-2. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 8 | Isothermal titration calorimetry quantified heat absorption that occurred during PA titration into TLR4/MD2, indicating that PA binds to TLR4/MD2. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 9 | Isothermal titration calorimetry quantified heat absorption that occurred during PA titration into TLR4/MD2, indicating that PA binds to TLR4/MD2. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 10 | Isothermal titration calorimetry quantified heat absorption that occurred during PA titration into TLR4/MD2, indicating that PA binds to TLR4/MD2. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 11 | Isothermal titration calorimetry quantified heat absorption that occurred during PA titration into TLR4/MD2, indicating that PA binds to TLR4/MD2. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 12 | Treatment of human MoDCs with PA resulted in endocytosis of TLR4, further supporting the function of PA as a TLR4 agonist. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 13 | Treatment of human MoDCs with PA resulted in endocytosis of TLR4, further supporting the function of PA as a TLR4 agonist. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 14 | Treatment of human MoDCs with PA resulted in endocytosis of TLR4, further supporting the function of PA as a TLR4 agonist. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 15 | Treatment of human MoDCs with PA resulted in endocytosis of TLR4, further supporting the function of PA as a TLR4 agonist. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 16 | Further experiments showed that PA induced TLR4 dependent secretion of the pro-inflammatory cytokine IL-1beta. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 17 | Lastly, our experimental data show that PA stimulation of NF-kappaB canonical pathway activation is regulated by TLR4 signaling and that reactive oxygen species may be important in upregulating this pro-inflammatory response. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 18 | Our experiments demonstrate for the first time that PA activation of TLR4 occurs in response to direct molecular interactions between PA and MD-2. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 19 | Our experiments demonstrate for the first time that PA activation of TLR4 occurs in response to direct molecular interactions between PA and MD-2. | Palmitic Acid | toll like receptor 4 | Homo sapiens |
| 20 | In summary, our findings suggest a likely molecular mechanism for PA induction of pro-inflammatory immune responses in human dendritic cells expressing TLR4. | Palmitic Acid | toll like receptor 4 | Homo sapiens |