Title : Synthesis of both enantiomers of 1,2,3,4-tetrahydroisoquinoline derivative IPPAM-1 and enantio-dependency of its positive allosteric modulation of prostacyclin receptor.

Pub. Date : 2017 Jun 1

PMID : 28462839






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1 Synthesis of both enantiomers of 1,2,3,4-tetrahydroisoquinoline derivative IPPAM-1 and enantio-dependency of its positive allosteric modulation of prostacyclin receptor. 1,2,3,4-tetrahydroisoquinoline prostaglandin I2 receptor Homo sapiens
2 We present a practical synthesis of both enantiomers of 1,2,3,4-tetrahydroisoquinoline derivative IPPAM-1 (1), which is a positive allosteric modulator (PAM) of prostacyclin receptor (IP) and a candidate for treatment of pulmonary arterial hypertension without the side effects caused by IP agonists. 1,2,3,4-tetrahydroisoquinoline prostaglandin I2 receptor Homo sapiens