Pub. Date : 2017
PMID : 28462695
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AMPA receptor and cAMP response element-binding protein (CREB) are involved in the antidepressant actions of Ketamine and imipramine, a traditional tricyclic antidepressant. | Imipramine | cAMP responsive element binding protein 1 | Homo sapiens |
| 2 | AMPA receptor and cAMP response element-binding protein (CREB) are involved in the antidepressant actions of Ketamine and imipramine, a traditional tricyclic antidepressant. | Imipramine | cAMP responsive element binding protein 1 | Homo sapiens |
| 3 | RESULTS: Here we show that the enhancement of the phosphorylation of CREB Ser133 and expression of CREB and glutamate receptor 1 (GluR1) are necessary for both ketamine"s and imipramine"s antidepressant actions, but the enhancements at early stage may account for the faster onset of ketamine"s antidepressant action than imipramine. | Imipramine | cAMP responsive element binding protein 1 | Homo sapiens |
| 4 | RESULTS: Here we show that the enhancement of the phosphorylation of CREB Ser133 and expression of CREB and glutamate receptor 1 (GluR1) are necessary for both ketamine"s and imipramine"s antidepressant actions, but the enhancements at early stage may account for the faster onset of ketamine"s antidepressant action than imipramine. | Imipramine | cAMP responsive element binding protein 1 | Homo sapiens |
| 5 | RESULTS: Here we show that the enhancement of the phosphorylation of CREB Ser133 and expression of CREB and glutamate receptor 1 (GluR1) are necessary for both ketamine"s and imipramine"s antidepressant actions, but the enhancements at early stage may account for the faster onset of ketamine"s antidepressant action than imipramine. | Imipramine | cAMP responsive element binding protein 1 | Homo sapiens |
| 6 | RESULTS: Here we show that the enhancement of the phosphorylation of CREB Ser133 and expression of CREB and glutamate receptor 1 (GluR1) are necessary for both ketamine"s and imipramine"s antidepressant actions, but the enhancements at early stage may account for the faster onset of ketamine"s antidepressant action than imipramine. | Imipramine | cAMP responsive element binding protein 1 | Homo sapiens |