Pub. Date : 2017 Aug 1
PMID : 28460056
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The induction of mitochondrial gene expression is more dependent on DMF"s target Nrf2 than hydroxycarboxylic acid receptor 2 (HCAR2). | Dimethyl Fumarate | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | Thus, DMF induces mitochondrial biogenesis primarily through its action on Nrf2, and is the first drug demonstrated to increase mitochondrial biogenesis with in vivo human dosing. | Dimethyl Fumarate | NFE2 like bZIP transcription factor 2 | Homo sapiens |