Pub. Date : 1988 Jul 15
PMID : 2845924
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Synergism between thrombin and adrenaline (epinephrine) in human platelets. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 2 | Adrenaline alone (3.5-4.0 microM) did not cause a change in any parameter (phosphoinositide metabolism, aggregation and dense-granule secretion), but markedly enhanced the thrombin-induced responses over a narrow range of thrombin concentrations (0.03-0.08 units/ml). | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 3 | Adrenaline alone (3.5-4.0 microM) did not cause a change in any parameter (phosphoinositide metabolism, aggregation and dense-granule secretion), but markedly enhanced the thrombin-induced responses over a narrow range of thrombin concentrations (0.03-0.08 units/ml). | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 4 | The thrombin-induced hydrolysis of inositol phospholipids by phospholipase C, which was measured as the formation of [32P]PA, was potentiated by adrenaline, as was the increase in the levels of [32P]PIP2 and [32P]PIP. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 5 | The presence of adrenaline caused a shift to the left for the thrombin-induced changes in the phosphoinositide metabolism, without affecting the maximal levels of 32P-labelled compounds obtained. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 6 | A similar shift by adrenaline in the dose-response relationship was previously demonstrated for thrombin-induced aggregation and dense-granule secretion. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 7 | Also, the narrow range of concentrations of thrombin over which adrenaline potentiates thrombin-induced platelet responses is the same for changes in phosphoinositide metabolism and physiological responses (aggregation and dense-granule secretion). | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 8 | Also, the narrow range of concentrations of thrombin over which adrenaline potentiates thrombin-induced platelet responses is the same for changes in phosphoinositide metabolism and physiological responses (aggregation and dense-granule secretion). | Epinephrine | coagulation factor II, thrombin | Homo sapiens |
| 9 | Our observations clearly indicate that adrenaline directly or indirectly influences thrombin-induced changes in phosphoinositide metabolism. | Epinephrine | coagulation factor II, thrombin | Homo sapiens |