Pub. Date : 2017
PMID : 28458525
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Rivastigmine: the advantages of dual inhibition of acetylcholinesterase and butyrylcholinesterase and its role in subcortical vascular dementia and Parkinson"s disease dementia. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 2 | Unlike donepezil and galantamine that selectively inhibit acetylcholinesterase (AChE; EC 3.1.1.7), rivastigmine is a unique cholinesterase inhibitor with both AChE and butyrylcholinesterase (BuChE; EC 3.1.1.8) inhibitory activity. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 3 | Additionally, we review the evidence supporting the use of dual AChE-BuChE inhibitory activity of rivastigmine as a therapeutic strategy in the treatment of neurological disorders, with a focus on the role of rivastigmine in subcortical dementias such as vascular dementia (VaD) and PDD. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |
| 4 | The available evidence from the literature suggests that the dual inhibition of AChE and BuChE may afford additional therapeutic potential of rivastigmine in subcortical dementias (subcortical VaD and PDD) with benefits on cognition and behavioral symptoms. | Rivastigmine | acetylcholinesterase (Cartwright blood group) | Homo sapiens |