Title : Erythropoietin activates SIRT1 to protect human cardiomyocytes against doxorubicin-induced mitochondrial dysfunction and toxicity.

Pub. Date : 2017 Jun 5

PMID : 28456571






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 EPO was found to upregulate SIRT1 activity and protein expression to reverse DOX-induced acetylation of PGC-1alpha and suppression of a suite of PGC-1alpha-activated genes involved in mitochondrial function and biogenesis, such as nuclear respiratory factor-1 (NRF1), mitochondrial transcription factor A (TFAM), citrate synthase (CS), superoxide dismutase 2 (SOD2), cytochrome c oxidase IV (COXIV), and voltage-dependent anion channel (VDAC). Doxorubicin superoxide dismutase 2 Homo sapiens
2 EPO was found to upregulate SIRT1 activity and protein expression to reverse DOX-induced acetylation of PGC-1alpha and suppression of a suite of PGC-1alpha-activated genes involved in mitochondrial function and biogenesis, such as nuclear respiratory factor-1 (NRF1), mitochondrial transcription factor A (TFAM), citrate synthase (CS), superoxide dismutase 2 (SOD2), cytochrome c oxidase IV (COXIV), and voltage-dependent anion channel (VDAC). Doxorubicin superoxide dismutase 2 Homo sapiens