Title : Allosteric Inhibition of Serotonin 5-HT7 Receptors by Zinc Ions.

Pub. Date : 2018 Apr

PMID : 28455702






2 Functional Relationships(s)
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1 Recently, we described zinc non-competitive interactions toward agonist binding at serotonin 5-HT1A receptors, in which biphasic effects, involving potentiation at sub-micromolar concentrations (10 muM) and inhibition at sub-millimolar concentrations (500 muM) of Zn2+ in radioligand binding assays, were consistent with both the agonist and antagonist-like effects of zinc ions observed in in vivo studies. Zinc latexin Homo sapiens
2 Recently, we described zinc non-competitive interactions toward agonist binding at serotonin 5-HT1A receptors, in which biphasic effects, involving potentiation at sub-micromolar concentrations (10 muM) and inhibition at sub-millimolar concentrations (500 muM) of Zn2+ in radioligand binding assays, were consistent with both the agonist and antagonist-like effects of zinc ions observed in in vivo studies. Zinc latexin Homo sapiens