Title : Grb2 carboxyl-terminal SH3 domain can bivalently associate with two ligands, in an SH3 dependent manner.

Pub. Date : 2017 Apr 28

PMID : 28455498






1 Functional Relationships(s)
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Protein Name
Organism
1 The C-terminal SH3 domain (SH3C) of Grb2 bivalently interacts with the atypical non-PxxP proline rich region of SLP65, and the N-terminal SH3 domain (SH3N) of Vav, both the interactions crucial for the proper functioning of the B cell. Proline growth factor receptor bound protein 2 Homo sapiens