Pub. Date : 2017 Jun 3
PMID : 28450110
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A hydrocortisone derivative binds to GAPDH and reduces the toxicity of extracellular polyglutamine-containing aggregates. | polyglutamine | glyceraldehyde-3-phosphate dehydrogenase | Rattus norvegicus |
| 2 | Here, we show that RX624, a derivative of hydrocortisone that binds to GAPDH, prevents the formation of aggregates of GAPDH-polyglutamine excreted into the culture medium by PC-12 rat cells expressing mutant huntingtin. | polyglutamine | glyceraldehyde-3-phosphate dehydrogenase | Rattus norvegicus |
| 3 | Here, we show that RX624, a derivative of hydrocortisone that binds to GAPDH, prevents the formation of aggregates of GAPDH-polyglutamine excreted into the culture medium by PC-12 rat cells expressing mutant huntingtin. | polyglutamine | glyceraldehyde-3-phosphate dehydrogenase | Rattus norvegicus |
| 4 | RX624 was previously shown to be unable to penetrate cells and, thus, its principal therapeutic action might be the inhibition of polyglutamine-GAPDH complex aggregation in the extracellular matrix. | polyglutamine | glyceraldehyde-3-phosphate dehydrogenase | Rattus norvegicus |