Pub. Date : 2017 Jul
PMID : 28446509
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of the all-trans Retinoic Acid (atRA) Hydroxylases CYP26A1 and CYP26B1 Results in Dynamic, Tissue-Specific Changes in Endogenous atRA Signaling. | Tretinoin | cytochrome P450, family 26, subfamily a, polypeptide 1 | Mus musculus |
| 2 | The cytochrome P450 family 26 (CYP26) enzymes are responsible for atRA clearance, and are potential drug targets to increase concentrations of endogenous atRA in a tissue-specific manner. | Tretinoin | cytochrome P450, family 26, subfamily a, polypeptide 1 | Mus musculus |
| 3 | The cytochrome P450 family 26 (CYP26) enzymes are responsible for atRA clearance, and are potential drug targets to increase concentrations of endogenous atRA in a tissue-specific manner. | Tretinoin | cytochrome P450, family 26, subfamily a, polypeptide 1 | Mus musculus |
| 4 | Following a single 2.5-mg/kg dose of talarozole to mice, atRA concentrations increased up to 5.7-, 2.7-, and 2.5-fold in serum, liver, and testis, respectively, resulting in induction of Cyp26a1 in the liver and testis and Rar beta and Pgc 1beta in liver. | Tretinoin | cytochrome P450, family 26, subfamily a, polypeptide 1 | Mus musculus |
| 5 | The increase in atRA concentrations was well predicted from talarozole pharmacokinetics and in vitro data of CYP26 inhibition. | Tretinoin | cytochrome P450, family 26, subfamily a, polypeptide 1 | Mus musculus |