Title : Polyglutamine tracts regulate beclin 1-dependent autophagy.

Pub. Date : 2017 May 4

PMID : 28445460






9 Functional Relationships(s)
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1 Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington"s disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). polyglutamine ataxin 3 Mus musculus
2 Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington"s disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). polyglutamine ataxin 3 Mus musculus
3 Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington"s disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). polyglutamine ataxin 3 Mus musculus
4 Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington"s disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). polyglutamine ataxin 3 Mus musculus
5 Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington"s disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). polyglutamine ataxin 3 Mus musculus
6 Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington"s disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). polyglutamine ataxin 3 Mus musculus
7 Here we show that the polyQ domain enables wild-type ataxin 3 to interact with beclin 1, a key initiator of autophagy. polyglutamine ataxin 3 Mus musculus
8 This activity of ataxin 3 and its polyQ-mediated interaction with beclin 1 was competed for by other soluble proteins with polyQ tracts in a length-dependent fashion. polyglutamine ataxin 3 Mus musculus
9 This activity of ataxin 3 and its polyQ-mediated interaction with beclin 1 was competed for by other soluble proteins with polyQ tracts in a length-dependent fashion. polyglutamine ataxin 3 Mus musculus