Title : Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.

Pub. Date : 1988 Sep

PMID : 2842790






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 TNF, IL-1, and forskolin all stimulated interleukin 6 (IL-6) mRNA levels in FS-4 cells. Colforsin interleukin 6 Homo sapiens
2 TNF, IL-1, and forskolin all stimulated interleukin 6 (IL-6) mRNA levels in FS-4 cells. Colforsin interleukin 6 Homo sapiens
3 The protein kinase inhibitor H-8, inhibiting preferentially cAMP-dependent kinase activity, reduced forskolin-stimulated IL-6 mRNA induction more strongly than TNF- or IL-1-driven IL-6 mRNA induction. Colforsin interleukin 6 Homo sapiens