Title : Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6.

Pub. Date : 1988 Sep

PMID : 2842790






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1 Enhancement of cAMP levels and of protein kinase activity by tumor necrosis factor and interleukin 1 in human fibroblasts: role in the induction of interleukin 6. Cyclic AMP interleukin 1 alpha Homo sapiens
2 Our present study shows that exposure of human FS-4 fibroblasts to TNF or IL-1 caused a rapid accumulation of intracellular cAMP and an increase in protein kinase activity. Cyclic AMP interleukin 1 alpha Homo sapiens
3 Intracellular cAMP levels peaked 3-5 min after the addition of TNF or IL-1 and returned to basal level by 15 min. Cyclic AMP interleukin 1 alpha Homo sapiens