Title : A multifunctional lipid nanoparticle for co-delivery of paclitaxel and curcumin for targeted delivery and enhanced cytotoxicity in multidrug resistant breast cancer cells.

Pub. Date : 2017 May 2

PMID : 28423731






3 Functional Relationships(s)
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Protein Name
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1 The faster release of curcumin from the folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles enables sufficient p-glycoprotein inhibition, which allows increased cellular uptake and cytotoxicity of paclitaxel. Curcumin ATP binding cassette subfamily B member 1 Homo sapiens
2 The faster release of curcumin from the folate-conjugated curcumin and paclitaxel-loaded lipid nanoparticles enables sufficient p-glycoprotein inhibition, which allows increased cellular uptake and cytotoxicity of paclitaxel. Curcumin ATP binding cassette subfamily B member 1 Homo sapiens
3 In western blot assay, curcumin can efficiently inhibit the expression of p-glycoprotein, conformed the enhancement of cytotoxicity by paclitaxel. Curcumin ATP binding cassette subfamily B member 1 Homo sapiens