Pub. Date : 2017 Mar
PMID : 28414290
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The SPR-based experiments have shown that a high concentration of isatin (270 mM) increases Kd values for complexes CYB5A/CYP3A5 and CYB5A/CYP3A4 (twofold and threefold, respectively), but has no influence on complex formation between CYB5A and other CYP (including indol-metabolizing CYP2C19 and CYP2E1). | Isatin | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |
| 2 | Molecular docking manipulations have shown that isatin can influence interaction of CYP3A5 or CYP3A4 with CYB5A acting at the contact region of CYB5A/CYP. | Isatin | cytochrome P450 family 3 subfamily A member 5 | Homo sapiens |