Title : Tetrandrine potentiates the glucocorticoid pharmacodynamics via inhibiting P-glycoprotein and mitogen-activated protein kinase in mitogen-activated human peripheral blood mononuclear cells.

Pub. Date : 2017 Jul 15

PMID : 28408143






3 Functional Relationships(s)
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Compound Name
Protein Name
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1 Tetrandrine potentiates the glucocorticoid pharmacodynamics via inhibiting P-glycoprotein and mitogen-activated protein kinase in mitogen-activated human peripheral blood mononuclear cells. tetrandrine ATP binding cassette subfamily B member 1 Homo sapiens
2 However tetrandrine with or without methylprednisolone significantly inhibited the function of drug efflux pump P-glycoprotein 170 of CD4+, CD8+ T cells and lymphocytes. tetrandrine ATP binding cassette subfamily B member 1 Homo sapiens
3 Glucocorticoids combined with tetrandrine could be a new therapeutic approach to resolve glucocorticoids-resistance possibly via inhibiting the function of P-glycoprotein and blocking mitogen-activated protein kinase signaling pathway from but not affecting on CD4+ CD25+ Foxp3+ regulatory cells. tetrandrine ATP binding cassette subfamily B member 1 Homo sapiens