Pub. Date : 2017
PMID : 28405246
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Modulation of benzo[a]pyrene-DNA adduct formation by CYP1 inducer and inhibitor. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | Therefore, AhR activators are suspected to have the potential to aggravate the toxicity of BaP through the induction of CYP1A1. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | Besides, CYP1A1 inhibitors, including its substrates, are estimated to have preventive effects against BaP toxicity. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 4 | To interpret these complicated outcomes, we propose a hypothesis that CYP1A1 is a key enzyme for both generation and reduction of (+-)-anti-benzo[a]pyrene-7,8-diol-9,10-epoxide (BPDE), the major carcinogenic intermediate of BaP. | Benzo(a)pyrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |