Title : Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity.

Pub. Date : 2017 Jun 1

PMID : 28400237






2 Functional Relationships(s)
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1 However, tacrine was removed from the market due to its hepatotoxicity concerns as it undergoes metabolism to toxic quinonemethide species through the cytochrome P450 enzyme CYP1A2. Tacrine cytochrome P450 family 1 subfamily A member 2 Homo sapiens
2 The hepatotoxic potential of tacrine derivatives was evaluated using recombinant cytochrome (CYP) P450 CYP1A2 and CYP3A4 enzymes. Tacrine cytochrome P450 family 1 subfamily A member 2 Homo sapiens