Title : Insulin directly reduces platelet sensitivity to aggregating agents. Studies in vitro and in vivo.

Pub. Date : 1988 Jun

PMID : 2838353






1 Functional Relationships(s)
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1 Our study rules out the possibility that insulin reduces platelet-function-modifying intraplatelet cAMP levels or thromboxane A2 production, because this hormone decreases the platelet concentrations of cAMP--a phenomenon that, per se, promotes platelet aggregation--and does not modify collagen or Na+ arachidonate--induced platelet production of thromboxane A2, measured by radioimmunoassay of its stable-metabolite thromboxane B2. Thromboxanes insulin Homo sapiens