Title : Increased Regenerative Capacity of the Olfactory Epithelium in Niemann-Pick Disease Type C1.

Pub. Date : 2017 Apr 6

PMID : 28383485






1 Functional Relationships(s)
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1 Additionally, after administration of two different therapy approaches using either a combination of miglustat, 2-hydroxypropyl-beta-cyclodextrin (HPbetaCD) and allopregnanolone or a monotherapy with HPbetaCD, we recorded a remarkable reduction of morphological damages in NPC1-/- mice and an up to four-fold increase of proliferating cells within the olfactory epithelium. 2-Hydroxypropyl-beta-cyclodextrin NPC1 like intracellular cholesterol transporter 1 Mus musculus