Title : Cardioprotective effect of KR-33889, a novel PARP inhibitor, against oxidative stress-induced apoptosis in H9c2 cells and isolated rat hearts.

Pub. Date : 2017 May

PMID : 28378219






2 Functional Relationships(s)
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1 However, KR-33889 pretreatment significantly attenuated H2O2-induced apoptosis of H9c2 cells, which was accompanied by decrease in expression of both cleaved caspase-3 and Bax and increase in Bcl-2 expression and the ratio of Bcl-2/Bax. Hydrogen Peroxide BCL2 associated X, apoptosis regulator Rattus norvegicus
2 However, KR-33889 pretreatment significantly attenuated H2O2-induced apoptosis of H9c2 cells, which was accompanied by decrease in expression of both cleaved caspase-3 and Bax and increase in Bcl-2 expression and the ratio of Bcl-2/Bax. Hydrogen Peroxide BCL2 associated X, apoptosis regulator Rattus norvegicus