Title : Oleanolic acid from antifilarial triterpene saponins of Dipterocarpus zeylanicus induces oxidative stress and apoptosis in filarial parasite Setaria digitata in vitro.

Pub. Date : 2017 Jun

PMID : 28351683






3 Functional Relationships(s)
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1 Acid hydrolysis of both compounds yielded oleanolic acid (3) which was non or least toxic to human peripheral blood mono nuclear cells (Selectivity index = >10) while retaining similar macrofilaricidal (IC50 = 38.4 muM) and microfilaricidal (IC50 = 35.6 muM) activities. Oleanolic Acid latexin Homo sapiens
2 Acid hydrolysis of both compounds yielded oleanolic acid (3) which was non or least toxic to human peripheral blood mono nuclear cells (Selectivity index = >10) while retaining similar macrofilaricidal (IC50 = 38.4 muM) and microfilaricidal (IC50 = 35.6 muM) activities. Oleanolic Acid latexin Homo sapiens
3 In adult female worms treated with 50 and 100 muM doses of oleanolic acid, condensation of nuclear DNA, apoptotic body formation and tissue damage was observed by using Hoechst 33342 staining, TUNEL assay and Hematoxylin and Eosin staining respectively. Oleanolic Acid latexin Homo sapiens