Pub. Date : 2017 Mar
PMID : 28349827
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Staurosporine suppresses survival of HepG2 cancer cells through Omi/HtrA2-mediated inhibition of PI3K/Akt signaling pathway. | Staurosporine | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We found that staurosporine significantly decreased cell viability and increased cell apoptosis in a concentration- and time-dependent manner in HepG2 cancer cells, along with the decreased expressions of PDK1 protein and Akt phosphorylation. | Staurosporine | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Taken together, our results indicate that staurosporine induced cytotoxicity response by inhibiting PI3K/Akt signaling pathway through Omi/HtrA2-mediated PDK1 degradation, and the process provides a novel mechanism by which staurosporine produces its therapeutic effects. | Staurosporine | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Taken together, our results indicate that staurosporine induced cytotoxicity response by inhibiting PI3K/Akt signaling pathway through Omi/HtrA2-mediated PDK1 degradation, and the process provides a novel mechanism by which staurosporine produces its therapeutic effects. | Staurosporine | AKT serine/threonine kinase 1 | Homo sapiens |