Pub. Date : 2017 Jul
PMID : 28347842
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Potential role of heme metabolism in the inducible expression of heme oxygenase-1. | Heme | heme oxygenase 1 | Homo sapiens |
| 2 | The enzyme heme oxygenase-1 (HO-1), involved in the degradation of heme, forms carbon monoxide (CO), ferrous iron, and bilirubin in conjunction with biliverdin reductase, and is induced by various stimuli including oxidative stress and heavy metals. | Heme | heme oxygenase 1 | Homo sapiens |
| 3 | We examined the involvement of heme metabolism in the induction of HO-1 by the inducers sulforaphane and sodium arsenite. | Heme | heme oxygenase 1 | Homo sapiens |
| 4 | RESULTS: The blockade of heme biosynthesis by succinylacetone and N-methyl protoporphyrin, which are inhibitors of heme biosynthesis, markedly decreased the induction of HO-1. | Heme | heme oxygenase 1 | Homo sapiens |
| 5 | RESULTS: The blockade of heme biosynthesis by succinylacetone and N-methyl protoporphyrin, which are inhibitors of heme biosynthesis, markedly decreased the induction of HO-1. | Heme | heme oxygenase 1 | Homo sapiens |
| 6 | The cessation of HO-1 induction occurred at the transcriptional and translational levels, and was mediated by the activation of the heme-binding transcriptional repressor Bach1 and translational factor HRI. | Heme | heme oxygenase 1 | Homo sapiens |
| 7 | CONCLUSIONS: We demonstrated the importance of heme metabolism in the stress-inducible expression of HO-1, and also that heme and its degradation products are protective factors for self-defense responses. | Heme | heme oxygenase 1 | Homo sapiens |
| 8 | GENERAL SIGNIFICANCE: The key role of heme metabolism in the stress-inducible expression of HO-1 may promote further studies on heme and its degradation products as protective factors of cellular stresses and iron homeostasis in specialized cells, organs, and whole animal systems. | Heme | heme oxygenase 1 | Homo sapiens |
| 9 | GENERAL SIGNIFICANCE: The key role of heme metabolism in the stress-inducible expression of HO-1 may promote further studies on heme and its degradation products as protective factors of cellular stresses and iron homeostasis in specialized cells, organs, and whole animal systems. | Heme | heme oxygenase 1 | Homo sapiens |